I have located a new and secure source to buy tramadol online. I will post it here just as soon as I’ve verified its process and quality.
I just wanted to take the time to review this medication I’ve been taking for my back pain. Here it’s called Tramal, but I believe it’s more popularly called Ultram. It’s pure tramadol HCL whereas other famous drugs like Ultracet are combined with paracetamol (similar to Tylenol or Aspirin if I’m not mistaken). I’ve got to say not only does this tramadol HCL in 100mg doses manage my pain well, it also gets me on an even keel high for around 4 hours. So not only am I feeling happy because the pain has subsided, but I’m also feeling, how do I describe it, not ‘high’ like loopy, but just like my mood is 5 notches better on a scale of 1-10 no matter what level it is when I first take the medication.
I do understand this drug tramadol is classified as an opiate and therefore poses a higher risk of addiction but I do not have an addictive personality so I hope that keeps my pain and any chance of becoming psychologically dependent on this pain killer. Time, and my doctor will tell.
The Ultram (tramol,tramal) here in Thailand, not to be confused with Ultracet (mixture of tramol and acetaminophen), Thailand tramal is available in pure 50mg capsules. They are available OTC (over the counter) and from a variety of Thai and international generic laboratories.
You can purchase tramadol HCL without a prescription, at rock bottom prices like I did because I am self employed and without a medical insurance plan and you simply need to contact us direct via our contact form here.
If you’re looking for discount generic medication made to world class, ISO standards at cheap prices you’ve come to the right place. Get your Cialis here at rock bottom prices.
What does Cialis do?
It’s like Viagra (sildenafil citrate), except your hear doesn’t beat faster and what you ate (oily foods etc) has absolutely not effect on the medication.
What’s best about Cialus is it doesn’t make you superman for a few hours, it lasts 36-72 hours!
Viagra simply has been around first and they spend a lot more money on marketing but if all things were equal in the medical world, Viagra would not even exist. Either way we carry Viagra for the people who don’t know about generic Cialis and how you can get it with no prescription needed. The only con is it takes 7-21 days to arrive. I order stuff from this pharmacy for my whole family and it arrives just as promised, every time. It doesn’t get more honest and professional as the guys at 4rx or I wouldn’t be making posts about quality of their product and support from start to finish. I don’t even get spammed by them which rocks too! Did I mentioned there was free shipping and bonus pills too?
More Cialis information;
How do Tadalafil work?
Treatment with Tadalafil is based on its effect on the human enzyme phosphodiesterase. Men are unable to get a strong enough erection due to the effect of this enzyme. Tadalafil works against this enzyme to help improve erections. This treatment was developed by Glaxo after details about Viagra’s run-away success hit the news. Approved by the FDA in 2003, Tadalafil has since then become well known in its own right. You can find many forums online that describe it as the “weekend pill” on account of its 36-72hour long effects. If you need any additional information about tadalafil, just continue reading the FAQs that follow.
Side Effects of Tadalafil
Tadalafil or its generic alternatives all have certain side effects, the most common of which are headache, back pains, muscle pains, congested nose and indigestion. The severity of these tadalafil side effects depends on the dosage taken. Tadalafil is a need-based medication; so if you take it as a regular dose, it would actually be an overdose. Moreover, it is meant to be used only by adult men on the prescription of a doctor; it should be avoided by those below the age of 18 years and especially by women during pregnancy as it could lead to more dangerous symptoms. Mixing alcohol with Tadalafil is also unadvisable as it could result in tadalafil side effects.
Guidelines before taking Tadalafil
Certain precautions should be taken prior to taking Tadalafil. The most important is that it should only be taken if you plan on indulging in sexual activity. It is not an aphrodisiac and so cannot increase your sex drive. Tadalafil can be taken with or without food, but heavy foods might slow down its working. If you are taking any nitrate medications for your cardiac condition, you should avoid taking Tadalafil as the interaction of the two drugs could lead to potentially fatal tadalafil side effects.
Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade name Valtrex or Zelitrex. As of November 25, 2009 (2009 -11-25)[update], Valacyclovir is being marketed in generic form in the United States by Ranbaxy Laboratories.
- Herpes simplex virus type I (HSV-1)
- Herpes simplex virus type II (HSV-2)
- Varicella zoster virus (VZV)
- Epstein-Barr virus (EBV)
- Cytomegalovirus (CMV)
Activity is predominantly active against HSV, and to a lesser extent VZV. It is only of limited efficacy against EBV and CMV, however, valacyclovir has recently been shown to lower or eliminate the presence of the Epstein-Barr virus in subjects afflicted with acute mononucleosis, leading to a significant decrease in the severity of symptoms. It is inactive against latent viruses in nerve ganglia.
As of 2005, resistance to valaciclovir has not been clinically significant. Mechanisms of resistance in HSV include deficient viral thymidine kinase; and mutations to viral thymidine kinase and/or DNA polymerase, altering substrate sensitivity.
Valaciclovir is indicated for the treatment of HSV and VZV infections, including:
- Genital herpes simplex (treatment and prophylaxis)
- Reduction of HSV transmission from people with recurrent infection to uninfected individuals
- Herpes zoster (shingles)
- Prevention of CMV disease following organ transplantation
Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea, anal leakage and/or headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects (<0.1% of patients) include: coma, seizures, neutropenia, leukopenia, tremor, ataxia, encephalopathy, psychotic symptoms, crystalluria, anorexia, fatigue, hepatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis and/or anaphylaxis.
Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra).
The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes.
People on antidepressants may experience sexual dysfunction, either as a result of their illness or as a result of their treatment. A 2003 study showed that sildenafil improved sexual function in men in this situation. Following up to earlier reports from 1999, the same researchers found that sildenafil was able to improve sexual function in female patients on antidepressants as well.
As well as erectile dysfunction, sildenafil citrate is also effective in the rare disease pulmonary arterial hypertension (PAH). It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This, in turn, reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure. Because PDE-5 is primarily distributed within the arterial wall smooth muscle of the lungs and penis, sildenafil acts selectively in both these areas without inducing vasodilation in other areas of the body. Pfizer submitted an additional registration for sildenafil to the FDA, and sildenafil was approved for this indication in June 2005. The preparation is named Revatio, to avoid confusion with Viagra, and the 20 milligram tablets are white and round. Sildenafil joins bosentan and prostacyclin-based therapies for this condition.
Sildenafil has been shown to be useful for the prevention and treatment of high-altitude pulmonary edema associated with altitude sickness such as that suffered by mountain climbers. While this effect has only recently been discovered, sildenafil is already becoming an accepted treatment for this condition, in particular in situations where the standard treatment of rapid descent has been delayed for some reason.
Use in sports
Professional sports players have been documented using drugs such as Viagra, with the thinking that the opening of their blood vessels will enrich their muscles. In turn, they believe that it will enhance their performance.
Viagra pills are blue and diamond-shaped with the words “Pfizer” engraved on one side, and “VGR xx” (where xx stands for “25″, “50″ or “100″, the dose of that pill in milligrams) engraved on the other. The dose of sildenafil for erectile dysfunction is 25 mg to 100 mg taken not more than once per day between 30 minutes and 4 hours prior to sexual intercourse.
The dosage for pulmonary arterial hypertension (Revatio) is one 20 mg tablet three times a day. Revatio pills are white, round, film-coated tablets imprinted with “RVT 20″ embossed on one side.
In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, dyspepsia, nasal congestion and impaired vision, including photophobia and blurred vision. Some sildenafil users have complained of seeing everything tinted blue (cyanopsia). Some complained of blurriness and loss of peripheral vision. In July 2005, the U.S. Food and Drug Administration found that sildenafil could lead to vision impairment in rare cases and a number of studies have linked sildenafil use with nonarteritic anterior ischemic optic neuropathy.
Rare but serious adverse effects found through postmarketing surveillance include priapism, severe hypotension, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. As a result of these postmarketing reports, in October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss.
Care should be exercised by patients that are also taking protease inhibitors for the treatment of HIV. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side-effects. It is recommended that patients using protease inhibitors limit their use of sildenafil to no more than one 25 mg dose every 48 hours.
Concomitant use of sildenafil and an alpha blocker may lead to low blood pressure, but this effect does not occur if they are taken at least four hours apart.
Tramadol (Ultram, Tramal, others below) is a centrally-acting analgesic, used for treating moderate to moderately severe pain. The drug has a wide range of applications, including treatment for restless leg syndrome, acid reflux, and fibermyosis.
Tramadol is a synthetic stripped-down piperidine-analog of the phenantherane alkaloid codeine and, as such, is an opioid and also a prodrug (codeine is metabolized to morphine, tramadol is converted to M-1 aka O-desmethyltramadol). Opioids are chemical compounds which act upon one or more of the human opiate receptors (the euphoria, addictive nature and respiratory depression are mainly caused by the Mu(μ) 1 and 2 receptor. The opioid agonistic effect of Tramadol and its major metabolite(s) are almost exclusively mediated by the substance’s action at the μ-opioid receptor. This characteristic distinguishes tramadol from many other substances (including morphine) of the opioid drug class, which generally do not possess tramadol’s degree of subtype selectivity.
Tramadol is used similarly to codeine, to treat moderate to moderately severe pain and most types of neuralgia, including trigeminal neuralgia. Tramadol is somewhat pharmacologically similar to levorphanol (albeit with much lower μ-agonism), as both opioids are also NMDA-antagonists which also have SNRI activity (other such opioids to do the same are Kratom, dextropropoxyphene (Darvon) & M1-like molecule tapentadol (Nucynta, a new synthetic atypical opioid made to mimic the agonistic properties of tramadol’s metabolite, M1(O-Desmethyltramadol). It has been suggested that tramadol could be effective for alleviating symptoms of depression, anxiety, and phobias because of its action on the noradrenergic and serotonergic systems, such as its “atypical” opioid activity. However, health professionals have not endorsed its use for these disorders, claiming it may be used as a unique treatment (only when other treatments failed), and must be used under the control of a psychiatrist.
In May 2009, the United States Food and Drug Administration issued a warning letter to Johnson & Johnson, alleging that a promotional website commissioned by the manufacturer had “overstated the efficacy” of the drug, and “minimized the serious risks”. The company which produced it, the German pharmaceutical company Grünenthal GmbH, were the ones alleged to be guilty of “minimizing” the addictive nature and proposed efficacy of the drug, although it showed little abuse liability in preliminary tests.
Availability and Usage
Tramadol is usually marketed as the hydrochloride salt (tramadol hydrochloride); the tartrate is seen on rare occasions, and rarely (in the US at least) tramadol is available for both injection (intravenous and/or intramuscular) and oral administration. The most well known dosing unit is the 50 mg generic tablet made by several manufacturers. It is also commonly available in conjunction with APAP (Paracetamol, Acetaminophen) as Ultracet, in the form of a smaller dose of 37.5 mg tramadol and 325 mg of APAP. The solutions suitable for injection are used in patient-controlled analgesia pumps under some circumstances, either as the sole agent or along with another agent such as morphine.
Tramadol comes in many forms, including:
- capsules (regular and extended release)
- tablets (regular, extended release, chewable, low-residue and/or uncoated tablets that can be taken by the sublingual and buccal routes)
- effervescent tablets and powders
- ampules of sterile solution for SC, IM, and IV injection
- preservative-free solutions for injection by the various spinal routes (epidural, intrathecal, caudal, and others)
- powders for compounding
- liquids both with and without alcohol for oral and sub-lingual administration, available in regular phials and bottles, dropper bottles, bottles with a pump similar to those used with liquid soap and phials with droppers built into the cap
- tablets and capsules containing (acetaminophen/APAP), aspirin and other agents.
Tramadol has been experimentally used in the form of an ingredient in multi-agent topical gels, creams, and solutions for nerve pain, rectal foam, concentrated retention enema, and a skin plaster (transdermal patch) quite similar to those used with lidocaine.
Tramadol has a characteristic taste which is mildly bitter but much less so than morphine and codeine. Oral and sublingual drops and liquid preparations come with and without added flavoring. Its relative effectiveness via transmucosal routes (i.e. sublingual, buccal, rectal) is similar to that of codeine, and, like codeine, it is also metabolized in the liver to stronger metabolites (see below).
The maximum dosage for tramadol in any form is 400 mg per day. Certain manufacturers or formulations have lower maximum doses. For example, Ultracet (37.5 mg/325 mg tramadol/APAP tablets) is capped at 8 tablets per day (300 mg/day). Ultram ER is available in 100, 200, and 300 mg/day doses and is explicitly capped at 300 mg/day as well.
Patients taking SSRIs (Prozac, Zoloft, etc.), SNRIs (Efexor, etc.), TCAs, MAOIs, or other strong opioids (oxycodone, methadone, fentanyl, morphine), as well as the elderly (> 75 years old), pediatric (< 18 years old), and those with severely reduced renal (kidney) or hepatic (liver) function should consult with their doctor regarding adjusted dosing or whether to use Tramadol at all.
Off-label and investigational uses
- diabetic neuropathy
- postherpetic neuralgia
- restless legs syndrome
- opiate withdrawal management /Anti-Depressant withdrawal aid (proven to be effective, especially with withdrawal from its distant relative Venlafaxine(Effexor).
- migraine headache
- obsessive-compulsive disorder
- premature ejaculation
Adverse effects and drug interactions
Main side effects of tramadol. Red color denotes more serious effects, requiring immediate contact with health provider.
The most commonly reported adverse drug reactions are nausea, vomiting, sweating and constipation. Drowsiness is reported, although it is less of an issue than for non-synthetic opioids. Patients prescribed tramadol for general pain relief along with other agents have reported uncontrollable withdrawal-like nervous tremors if weaning off the medication happens too quickly. Respiratory depression, a common side-effect of most opioids, is not clinically significant in normal doses. By itself, it can decrease the seizure threshold. When combined with SSRIs, tricyclic antidepressants, or in patients with epilepsy, the seizure threshold is further decreased. Seizures have been reported in humans receiving excessive single oral doses (700 mg) or large intravenous doses (300 mg). However, there have been several rare cases of people having grand-mal seizures at doses as low as 100–400 mg orally. An Australian study found that of 97 confirmed new-onset seizures, eight were associated with tramadol, and that in the authors’ First Seizure Clinic, “tramadol is the most frequently suspected cause of provoked seizures” (Labate 2005). There appears to be growing evidence that Tramadol use may have serious risks in some individuals. Seizures caused by tramadol are most often tonic-clonic seizures, more commonly known in the past as grand mal seizures. Also when taken with SSRIs, there is an increased risk of serotonin toxicity, which can be fatal. Fewer than 1% of users have a presumed incident seizure claim after their first tramadol prescription. Risk of seizure claim increases 2- to 6-fold among users adjusted for selected comorbidities and concomitant drugs. Risk of seizure is highest among those aged 25–54 years, those with more than four tramadol prescriptions, and those with a history of alcohol abuse, stroke, or head injury. Dosages of warfarin may need to be reduced for anticoagulated patients to avoid bleeding complications. Constipation can be severe especially in the elderly requiring manual evacuation of the bowel. Furthermore, there are suggestions that chronic opioid administration may induce a state of immune tolerance, although tramadol, in contrast to typical opioids may enhance immune function. Some have also stressed the negative effects of opioids on cognitive functioning and personality.
Tetracycline (INN) (pronounced /ˌtɛtrəˈsaɪkliːn/) is a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria, indicated for use against many bacterial infections. It is a protein synthesis inhibitor. It is commonly used to treat acne today, and, more recently, rosacea, and played a historical role in stamping out cholera in the developed world. It is sold under the brand names Sumycin, Terramycin, Tetracyn, and Panmycin, among others. Actisite is a thread-like fiber form, used in dental applications. It is also used to produce several semi-synthetic derivatives, which together are known as the tetracycline antibiotics.
Mechanism of action
Tetracyclines work by binding the 30S ribosomal subunit and through an interaction with 16S rRNA, they prevent the docking of amino-acylated tRNA.
Resistance to tetracyclines can arise through drug efflux, ribosomal protection proteins, 16S rRNA mutation, and drug inactivation through the action of a monooxygenase.
Cautions, contraindications, side-effects
Are as those of the tetracycline antibiotics group:
- Can stain developing teeth (even when taken by the mother during pregnancy)
- Can cause permanent teeth discoloration (yellow-gray-brown); infancy and childhood to eight (8) years old
- Inactivated by Ca2+ ion, not to be taken with milk, yogurt, and other dairy products
- Inactivated by aluminium, iron and zinc, not to be taken at the same time as indigestion remedies
- Inactivated by common antacids and over-the-counter heartburn medicines.
- Skin photosensitivity; exposure to the Sun or intense light is not recommended
- Drug-induced lupus, and hepatitis
- May interfere with methotrexate by displacing it from the various protein binding sites
- Can cause breathing complications as well as anaphylactic shock in some individuals
- Should be avoided during pregnancy as it may affect bone growth of fetus.
- Passes into breast milk and is harmful to breast-fed infants, and should therefore be avoided during breastfeeding if possible.
Wellbutrin is just one brand name for the generic drug bupropion.
Brand Names for products containing bupropion are: Zyban SR Wellbutrin SR, Wellbutrin XL
More info about Wellbutrin
- Wellbutrin is an antidepressant.
- Wellbutrin may be prescribed by your doctor to combat feelings of sorrow, guilt, or worthlessness, appetite problems, constant tiredness, sleeplessness, or suicidal thoughts.
- Some doctors may prescribe Wellbutrin to help decrease the effects of nicotine withdrawals for patients who want to cease smoking.
-As with all prescription drugs, use Wellbutrin exactly as directed by your physician.
- Take a full glass of water with with each dose of Wellbutrin or Zyban.
- This medicine may be taken with or without food.
- Individual and daily dosage must never surpass that recommended by your physician. Consuming more Wellbutrin than prescribed by your doctor may cause seizures.
- The undigested tablet shell of your dose of Wellbutrin could pass through your body during a regular bowel movement. The covering may look like a whole tablet or pill. Thee is no need to consult with your doctor as this is normal with Wellbutrin.
- Keep the drug at room temperature. Do not expose to heat and/or moisture.
- Wellbutrin may have a noticeable odor. This is normal.
- When using Wellbutrin to stop smoking, you must consult your physician before combining your Wellbutrin therapy with other types of smoking cessation aids such as nicotine gum or patches.
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